HopeAI Workspace / Phase 3 development90-SECOND PRODUCT DEMO · NARRATION INCLUDED
WorkspaceDEVELOPMENT / EARLY-LINE RRMM Demo simulation HA
01 / THE QUESTION

A Phase 3 plan starts with one question

Clinical evidence, trial design, and business planning in one workspace

01/ 09
YOUR QUESTION

Design a Phase 3 trial for early-line RRMM.

BCMA×CD3 bispecific antibody
+ daratumumab
SCIENTIFIC CONTEXT ATTACHED
Population of interestRelapsed or refractory multiple myeloma
1–3 prior lines of therapy
Publication + protocol

01 Clarify the question

Interpret intent
Identify evidence gaps
Set planning assumptions

CMO orchestrator

CMO

ORCHESTRATOR

Ready to plan

Decompose & plan

Define workstreams
Connect agents and apps
Manage dependencies

CMO DISPATCHES AGENTS5 SPECIALIST WORKSTREAMS
Development planWORKSPACE APP

A connected execution plan

Shared assumptions. Clear handoffs.
1
Establish the clinical foundation

Mechanism, population, comparator, benchmark

2
Test the study design

Sample size, scenarios, patient burden, feasibility

3
Build the development decision

Timeline, investment, market potential, review

Clinical benchmark → Statistics → Operations → Forecast

Define the clinical strategy

BCMA×CD3 redirects T cells to BCMA-expressing myeloma cells
T cell · CD3BCMA×CD3
bispecific antibodyBCMA · myeloma
CONTROL-ARM OPTIONSPlanning-era evidence
RegimenAssessment
Daratumumab + PdCandidate control
Daratumumab + VdAlternative by eligibility
Proposed control: investigator-selected DPd or DVd

Pd: pomalidomide + dexamethasone · Vd: bortezomib + dexamethasone

Size the trial. Test uncertainty.

Illustrative design inputs · PFS · 1:1 randomization
560ENROLLMENT SCENARIO
335TARGET PFS EVENTS
90%TARGET POWER
100%90%80%250 events335425
ConservativeBaseOptimistic

Illustrative curves · simulation workflow shown, not executed
Target HR 0.70 · two-sided α 0.05 · interim monitoring to be specified

Make the design deliverable

Safety and patient experience inform the operating plan
Patient journey

Step-up dosing & observation
Visits, travel & caregiver time
Labs & marrow assessments

Safety requirements

CRS & neurotoxicity monitoring
Infection prevention
Immunoglobulin management

M0M12M24M36M48
Start-up
Enrollment
Follow-up
Evaluate fewer visits without weakening safety monitoring

Illustrative planning schedule · recruitment and event timing drive readout

Review endpoints and evidence

Regulatory input to the integrated study design
Primary endpointIndependent-review PFS
EstimandIntercurrent events specified
MultiplicityTesting hierarchy defined
Safety oversightMonitoring and stopping rules
Evidence requirements → Protocol synopsis

Illustrative planning proposal · specialist review required

Connect science to investment

Eligible patients → access → uptake → net sales
Patient flowTreatment durationNet price
Net sales · relative index100330LaunchYear 5Year 10
DownsideBaseUpside
Development cost and launch timing linked to the operating plan

Illustrative forecast shape · not a valuation or revenue estimate

Challenge. Revise. Integrate.

Scientific Reviewer checks the shared evidence
Methodology and source authorityCHECKED
Assumptions across workstreamsALIGNED
Review question: can we reduce visits?

CMO re-dispatches Safety and Operations.
Visit consolidation assessed; required safety observation retained.

Patient burden + operating planRevised together
Integrated proposal prepared for human review

Scientific Reviewer

Collect, normalize, and evaluate evidence across every workstream

WAITING FOR OUTPUTS
Reviewer flags a gap
CMO re-dispatches
SHARED CONTEXTScientific & clinical evidenceTrial design & executionApproval & market reality
Introducing HopeAI Workspace

Your trusted AI team for clinical development

Five domains, one workspace

Describe what you’d like to accomplish…＋ Attach scientific context
Clinical · Biostatistics · Operations · Regulatory · Commercialization

Your study documents

Study publication

Clinical and scientific context

Trial protocol

Design assumptions and study details

BCMA×CD3 · early-line RRMM
START WITH THE STUDY CONTEXT

Validated evidence

Clinical evidence

Comparable trials · treatment pathways

Regulatory and safety

Endpoints · monitoring requirements

Market context

Patient demand · access

GROUND THE PLANNING ASSUMPTIONS

Connected tools

Design and simulation

Sample size · trial scenarios

Patient experience and delivery

Burden · enrollment · timeline

Business case

Sales · development costs

SUPPORT THE SPECIALIST WORKSTREAMS
Shared Context

Documents · Evidence · Tools

ASK HOPEAI WORKSPACE
Control arm · Sample size · Patient burden · Timeline · Sales outlook
BCMA×CD3 bispecific + daratumumab1–3 prior linesPublication + protocol attached
One question. A connected development team.
A Phase 3 proposal, ready for your team
Six linked artifacts. Shared assumptions. Traceable decisions.
Traceable evidenceShared assumptionsHuman review
HopeAIWorkspace

Your trusted AI team for clinical development

Five functions | One workspace

0:00 / 1:30
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Recording notes & narration

Recording: Open this file in Chrome or Edge. Select Fullscreen for a clean 16:9 frame, then press Space to play. Use R to toggle clean view, C for captions, F for fullscreen, and ← / → to seek by one second. The film stops at 90 seconds. The opening types Introducing, HopeAI, and Workspace, then lets the completed title settle before a gradual dissolve into the workspace. The title sequence lasts about four and a half seconds without a duplicate subtitle. The six-artifact proposal page is retained without its bottom logo. A five-function recap accompanies the closing team tagline, followed by the supplied HopeAI closing slide, with a separate logo and tagline reveal aligned to the music. Spoken narration and short interface sound effects are embedded in this file and synchronized to the film. Clicks and scene transitions use clear, distinct cues, aligned with the glowing-dot handoffs and narration. The opening and closing use short music excerpts from your uploaded reference, automatically lowered under speech. Use Audio on/off (M) to mute. Test effects plays isolated clicks, keyboard typing, and transition cues so you can check your speaker level. The full script is below; audio, script, and subtitles can also be downloaded. The HTML is self-contained and works offline.

Demo status: This is a scripted product mockup inspired by slides 1, 3, and 4 of the supplied deck. The narration uses a warm, conversational neural English voice, generated for this demo. Playback, captions, and scene timing follow the embedded audio. The study documents and evidence sources form shared planning context; the specialists perform the detailed analysis in the later functional scenes. Agents, app activity, review outcomes, chart curves, and forecast shapes are illustrative. The sample-size scenario is a background design example, not a fresh simulation. No live searches, simulations, or commercial forecasts run in this file. Clinical planning requires specialist review.